N-ethylmaleimide activates a Cl−-independent component of K+ flux in mouse erythrocytes
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منابع مشابه
Volume-Sensitive K+/Cl− Cotransport in Rabbit Erythrocytes
The kinetics of activation and inactivation of K(+)/Cl(-) cotransport (KCC) have been measured in rabbit red blood cells for the purpose of determining the individual rate constants for the rate-limiting activation and inactivation events. Four different interventions (cell swelling, N-ethylmaleimide [NEM], low intracellular pH, and low intracellular Mg(2+)) all activate KCC with a single expon...
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In this paper, we study an (n-k+1)-out-of-n system by adopting their components to be statistically independent though nonidentically distributed. By assuming that at least m components at a fixed time have failed while the system is still working, we obtain the mixture representation of survival function for a quantity called the conditional inactivity time of failed components in the system. ...
متن کاملKinetics of Cl-dependent K fluxes in hyposmotically swollen low K sheep erythrocytes
A detailed kinetic study of K:Cl cotransport in hyposmotically swollen low K sheep red blood cells was carried out to characterize the nature of the outwardly poised carrier. The kinetic parameters were determined from the rate of K efflux and influx under zero-K-trans conditions in red cells with cellular K altered by the nystatin method and with different extracellular K or Rb concentrations....
متن کاملSwelling activation of K-Cl cotransport in LK sheep erythrocytes: a three-state process
K-Cl cotransport in LK sheep erythrocytes is activated by osmotic swelling and inhibited by shrinkage. The mechanism by which changes in cell volume are transduced into changes in transport was investigated by measuring time courses of changes in transport after osmotic challenges in cells with normal and reduced Mg concentrations. When cells of normal volume and normal Mg are swollen, there is...
متن کاملSolvent drag component of Cl- flux in superficial proximal straight tubules: evidence for a paracellular component of isotonic fluid absorption.
ANDREOLI, THOMAS E., JAMES A. SCHAFER, SUSAN L. TROUTMAN, AND MARY L. WATKINS. Solvent drag component of Clflux in superficial proximal straight tubules: evidence for a paracellular component of isotonic fluid absorption. Am. J. Physiol. 237(6): F455-F462, 1979 or Am. J. Physiol.: Renal Fluid Electrolyte Physiol. 6(6): F455-F462, 1979.-We have computed the fraction of isotonic fluid absorption ...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2013
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2013.02.004